Badder bosses isn’t hard, it just requires more strategy. For slime, you always need to be able to duck behind a corner in a single turn, so you can loop the boss around a single tile of grass to achieve this. Tengu just have a blink stone or two. Caves boss isn’t much harder, neither is dwarven boss. For the eye, just kill the spawners before starting the boss fight and study the description of each fist before making a move. Swarm intelligence just makes it so you get swarmed when entering a floor for the first time, after that the floor gets easier to clear. Hostile champions does add considerable difficulty, so don’t go for that one first. Forbidden runes is pretty easy to work with, so is into darkness. Barren land is easy as well, you just don’t get the extra healing from dew drops and sunflower, so just craft any sunflower seeds you get into heal pots. For what to not do, pharmiciphoba is Uber hard, so is faith is my armor. On diet is hard in combination with into darkness and barren land, so I avoid it.