I got Skyrim from GOG, and am not able to run it with Wine, I remember running Skyrim AE GOG a couple months ago, and don’t what changed. I get this running SkyrimSE.exe from terminal

info:  Game: SkyrimSE.exe
info:  DXVK: v2.2
info:  Vulkan: Found vkGetInstanceProcAddr in winevulkan.dll @ 0x2d4ad3f50
info:  Built-in extension providers:
info:    Win32 WSI
info:    OpenVR
info:    OpenXR
info:  OpenVR: could not open registry key, status 2
info:  OpenVR: Failed to locate module
info:  Enabled instance extensions:
info:    VK_KHR_get_surface_capabilities2
info:    VK_KHR_surface
info:    VK_KHR_win32_surface
ac_compute_device_uuid's output is based on invalid pci bus info.
info:  AMD Radeon Graphics:
info:    Driver : AMD open-source driver 2.0.267
info:    Memory Heap[0]: 
info:      Size: 7656 MiB
info:      Flags: 0x0
info:      Memory Type[1]: Property Flags = 0x6
info:      Memory Type[3]: Property Flags = 0xe
info:      Memory Type[5]: Property Flags = 0xc6
info:      Memory Type[7]: Property Flags = 0xce
info:      Memory Type[9]: Property Flags = 0x6
info:      Memory Type[11]: Property Flags = 0xe
info:      Memory Type[13]: Property Flags = 0xc6
info:      Memory Type[15]: Property Flags = 0xce
info:    Memory Heap[1]: 
info:      Size: 512 MiB
info:      Flags: 0x3
info:      Memory Type[0]: Property Flags = 0x1
info:      Memory Type[2]: Property Flags = 0x7
info:      Memory Type[4]: Property Flags = 0xc1
info:      Memory Type[6]: Property Flags = 0xc7
info:      Memory Type[8]: Property Flags = 0x1
info:      Memory Type[10]: Property Flags = 0x7
info:      Memory Type[12]: Property Flags = 0xc1
info:      Memory Type[14]: Property Flags = 0xc7
05c0:fixme:system:QueryDisplayConfig (00000002 0000000000218548 00000000023ED9C0 000000000021854C 00000000019D3B60 0000000000000000): semi-stub
05c0:fixme:system:QueryDisplayConfig (00000002 0000000000218548 00000000023ED9C0 000000000021854C 00000000019D3B60 0000000000000000): semi-stub
05c0:fixme:system:QueryDisplayConfig (00000002 00000000002185C8 00000000023ED9C0 00000000002185CC 00000000019D3B60 0000000000000000): semi-stub
05c0:fixme:system:QueryDisplayConfig (00000002 00000000002151BC 00000000023ED9C0 0000000000215220 00000000019D3B60 0000000000000000): semi-stub
warn:  D3D11DeviceFeatures: External memory features not supported
info:  D3D11CoreCreateDevice: Maximum supported feature level: D3D_FEATURE_LEVEL_12_0
info:  D3D11CoreCreateDevice: Using feature level D3D_FEATURE_LEVEL_11_0
info:  Device properties:
info:    Device : AMD Radeon Graphics
info:    Driver : AMD open-source driver 2.0.267
info:  Enabled device extensions:
info:    VK_AMD_memory_overallocation_behavior
info:    VK_AMD_shader_fragment_mask
info:    VK_EXT_attachment_feedback_loop_layout
info:    VK_EXT_conservative_rasterization
info:    VK_EXT_custom_border_color
info:    VK_EXT_depth_clip_enable
info:    VK_EXT_extended_dynamic_state3
info:    VK_EXT_hdr_metadata
info:    VK_EXT_memory_priority
info:    VK_EXT_non_seamless_cube_map
info:    VK_EXT_robustness2
info:    VK_EXT_shader_module_identifier
info:    VK_EXT_shader_stencil_export
info:    VK_EXT_transform_feedback
info:    VK_EXT_vertex_attribute_divisor
info:    VK_KHR_pipeline_library
info:    VK_KHR_swapchain
info:  Device features:
info:    robustBufferAccess                     : 1
info:    fullDrawIndexUint32                    : 1
info:    imageCubeArray                         : 1
info:    independentBlend                       : 1
info:    geometryShader                         : 1
info:    tessellationShader                     : 1
info:    sampleRateShading                      : 1
info:    dualSrcBlend                           : 1
info:    logicOp                                : 1
info:    multiDrawIndirect                      : 1
info:    drawIndirectFirstInstance              : 1
info:    depthClamp                             : 1
info:    depthBiasClamp                         : 1
info:    fillModeNonSolid                       : 1
info:    depthBounds                            : 1
info:    multiViewport                          : 1
info:    samplerAnisotropy                      : 1
info:    textureCompressionBC                   : 1
info:    occlusionQueryPrecise                  : 1
info:    pipelineStatisticsQuery                : 1
info:    vertexPipelineStoresAndAtomics         : 1
info:    fragmentStoresAndAtomics               : 1
info:    shaderImageGatherExtended              : 1
info:    shaderClipDistance                     : 1
info:    shaderCullDistance                     : 1
info:    shaderFloat64                          : 1
info:    shaderInt64                            : 1
info:    variableMultisampleRate                : 1
info:    shaderResourceResidency                : 1
info:    shaderResourceMinLod                   : 1
info:    sparseBinding                          : 1
info:    sparseResidencyBuffer                  : 1
info:    sparseResidencyImage2D                 : 1
info:    sparseResidencyImage3D                 : 1
info:    sparseResidency2Samples                : 0
info:    sparseResidency4Samples                : 0
info:    sparseResidency8Samples                : 0
info:    sparseResidency16Samples               : 0
info:    sparseResidencyAliased                 : 1
info:  Vulkan 1.1
info:    shaderDrawParameters                   : 1
info:  Vulkan 1.2
info:    samplerMirrorClampToEdge               : 1
info:    drawIndirectCount                      : 1
info:    samplerFilterMinmax                    : 1
info:    hostQueryReset                         : 1
info:    timelineSemaphore                      : 1
info:    bufferDeviceAddress                    : 0
info:    shaderOutputViewportIndex              : 1
info:    shaderOutputLayer                      : 1
info:    vulkanMemoryModel                      : 1
info:  Vulkan 1.3
info:    robustImageAccess                      : 0
info:    pipelineCreationCacheControl           : 1
info:    shaderDemoteToHelperInvocation         : 1
info:    shaderZeroInitializeWorkgroupMemory    : 0
info:    synchronization2                       : 1
info:    dynamicRendering                       : 1
info:  VK_AMD_shader_fragment_mask
info:    extension supported                    : 1
info:  VK_EXT_attachment_feedback_loop_layout
info:    attachmentFeedbackLoopLayout           : 0
info:  VK_EXT_conservative_rasterization
info:    extension supported                    : 1
info:  VK_EXT_custom_border_color
info:    customBorderColors                     : 1
info:    customBorderColorWithoutFormat         : 1
info:  VK_EXT_depth_clip_enable
info:    depthClipEnable                        : 1
info:  VK_EXT_extended_dynamic_state3
info:    extDynamicState3AlphaToCoverageEnable  : 1
info:    extDynamicState3DepthClipEnable        : 1
info:    extDynamicState3RasterizationSamples   : 1
info:    extDynamicState3SampleMask             : 1
info:  VK_EXT_fragment_shader_interlock
info:    fragmentShaderSampleInterlock          : 0
info:    fragmentShaderPixelInterlock           : 0
info:  VK_EXT_full_screen_exclusive
info:    extension supported                    : 0
info:  VK_EXT_graphics_pipeline_library
info:    graphicsPipelineLibrary                : 0
info:  VK_EXT_memory_budget
info:    extension supported                    : 1
info:  VK_EXT_memory_priority
info:    memoryPriority                         : 1
info:  VK_EXT_non_seamless_cube_map
info:    nonSeamlessCubeMap                     : 0
info:  VK_EXT_robustness2
info:    robustBufferAccess2                    : 1
info:    robustImageAccess2                     : 1
info:    nullDescriptor                         : 1
info:  VK_EXT_shader_module_identifier
info:    shaderModuleIdentifier                 : 1
info:  VK_EXT_shader_stencil_export
info:    extension supported                    : 1
info:  VK_EXT_swapchain_colorspace
info:    extension supported                    : 0
info:  VK_EXT_hdr_metadata
info:    extension supported                    : 1
info:  VK_EXT_transform_feedback
info:    transformFeedback                      : 1
info:    geometryStreams                        : 1
info:  VK_EXT_vertex_attribute_divisor
info:    vertexAttributeInstanceRateDivisor     : 1
info:    vertexAttributeInstanceRateZeroDivisor : 1
info:  VK_KHR_external_memory_win32
info:    extension supported                    : 0
info:  VK_KHR_external_semaphore_win32
info:    extension supported                    : 0
info:  VK_NVX_binary_import
info:    extension supported                    : 0
info:  VK_NVX_image_view_handle
info:    extension supported                    : 0
info:  Queue families:
info:    Graphics : 0
info:    Transfer : 2
info:    Sparse   : 0
info:  Memory type mask for sparse resources: 0xf
warn:  DXVK: No state cache file found
info:  DXVK: Graphics pipeline libraries not supported
info:  DXGI: VK_FORMAT_D24_UNORM_S8_UINT -> VK_FORMAT_D32_SFLOAT_S8_UINT
info:  Presenter: Actual swap chain properties:
info:    Format:       VK_FORMAT_B8G8R8A8_UNORM
info:    Color space:  VK_COLOR_SPACE_SRGB_NONLINEAR_KHR
info:    Present mode: VK_PRESENT_MODE_IMMEDIATE_KHR
info:    Buffer size:  1920x1080
info:    Image count:  3
info:    Exclusive FS: 1
05c0:fixme:system:QueryDisplayConfig (00000002 0000000000217F08 00000000023F9660 0000000000217F0C 0000000002451390 0000000000000000): semi-stub
info:  Setting display mode: 1920x1080@60
info:  Setting display mode: 1920x1080@60
05c0:fixme:system:QueryDisplayConfig (00000002 0000000000218468 00000000023F9660 000000000021846C 0000000002451410 0000000000000000): semi-stub
info:  Setting display mode: 1920x1080@60
info:  Setting display mode: 1920x1080@60
warn:  DXGI: MakeWindowAssociation: Ignoring flags