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Technicly yes but it’d be hard and would probably break a lot of stuff. If you need a diffrent package manager its better to just install a distro that comes with it.
Yes, but you are asking for a world of pain. Why would you want to do this?
Yeah, wipe your current distro and install another.
Yes it probably is but there is really no sense in replacing all the packages
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nixpkgs in my experience has more packages than most other distributions. For example they ship a ton of OBS plugins