It too me a while to work out why my Nextcloud stuff wasn’t working on my phone. It wasn’t until I went to http://duckdns.org on mobile data I saw the block. I had changed ISP from one with IPv6, which I had setup, to an ISP without it, and thought it might be that. But it was just coincidence.
I’ve written to O2 but I doubt they will change anything, so I’ll be changing network.
So heads up UK O2 self hosting people!
Giffgaff uses o2 and also blocks duckdns. Additionally, whatever blocklist my employer is using also blocks it, so it’s probably a common thing now.