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Cake day: September 13th, 2023

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  • My understanding is by medical standards, the evidence is pretty low quality, which is why GnRH agonists aren’t approved by the EMA, MHRA, FDA, or NICE for gender dysphoria.

    It highlights a wider issue in medicine though, the obsession with randomised controlled trials, which is basically the only evidence the GRADE method considers “high quality”. We are seeing exactly the same problem with MDMA assisted therapy, any therapy where blinding is difficult is dismissed by the medical establishment. NICE dismissed (es)ketamine for depression for the same reason. Add to that the fact that GnRH agonists are off patent, so there’s no incentive for industry to fund studies.






  • Kodak made a lot of attempts to move people to smaller film sizes, so they could sell less film for the same price. They made claims that their advances in film technology made the photos the same resolution as you would previously get in 35mm, which was sort of true, but that meant you could just stick with 35mm and get better resolution photos.

    Ironically the only one that kind of worked was APS, it wasn’t that successful as a film format, but it was responsible for the APS digital sensor size.