Contact by Carl Sagan

The Post-Self series by Madison Scott-Clary. This page has short descriptions of the books and links to where you can buy them: https://post-self.ink/

It is broadly about a future where people can upload there minds to a computer system, which makes them (barring some specific and rare circumstances) immortal and allows them to make copies of their uploaded selves. There are multiple non-binary protagonists, one of them also being aromantic and asexual. There are also polyamorous, bisexual and gay characters.

I don’t have a single favorite one, so here is a top three, in no particular order:

Freefall The first webcomic i read, started in 1998 and still updating three times a week.

El Goonish Shive Another longrunner, started 2002 and still going. Helped me with figuring out some gender stuff.

How to be a werewolf Newest one on the list, starting in 2015, also still going.