Two pills of 50mg will double compared to the one 50mg…of that active drug. That number doesn’t translate over the same to a different active drug. Just look at LD50s for that concept.

I don’t live in the UK, would you be willing to give an example of what the yearly lump sum is vs the monthly fee? I’m genuinely curious!

Shepherd’s Crossing 2, for the DS. I’ve put a truly ridiculous number of hours into it over the years, and keep coming back.

It’s not popular in the farm sims because a key part is butchering your meat animals so you can feed your dogs.

Fair opinion, it can be a little rough to follow along if you’re not in the mood for comedy. Rating things as cringe is so dead tho.

If you work on your feet/have to stand on concrete/tile, definitely look at “Heel That Pain” brand heel seats. Full price is way too much (44$ for two boxes), so look for sales.

There’s a gel one and a more firm one. The gel one helped with sciatic pain, and still works ~3 pairs of shoes later.

(I’ve also layered the heel seats over top of the typical Dr. Scholl’s work gel inserts. Works great for me but my partner hates the feel. YMMV.)

The mushy flipflops!! I can’t believe I forgot about those things. I had a pair as a gift when I graduated and they lasted me years. Once they died I wanted a new pair. Coughed up for the same brand and they…leave weird black rubber bits on everything.

Unfortunately, I can’t afford the price just to try Hokas. They were recommended by another nursing student, and seem to be a gold standard shoe for a lot of healthcare workers.

From what I’ve heard, though, it “depends on your usage”.

What do you do to make your 20$ shoes last as long as you can? And tips and tricks?

Super neat!! Thanks for the link. :) If anyone likes the style of writing, go look at the Discworld community. These books are great.

I’m hoping this quote can drive some critical thinking about sustainability, and maybe some discussion about how to better what people CAN afford/already have.

Here’s my example: Nice Hoka shoes are typically 100$+, but Sketcher’s Work Sneakers are ~40$. The Hokas would last a lot longer and be more ergonomic, but that price is way out of my reach. The Sketchers get disintegrated by a year of use.

What I do is add arch supports and gel shoe inserts (9$ iirc) into the Sketchers, and replace those when they wear. It adds about two years of life to the shoes! :)

Very interesting documentary on YouTube about using wood, wind, and sunlight as the sole powers to support a house and a family. Definitely sustainable! Thanks for sharing.

One good way for people in apartments to start some sustainable living is regrowing veg whenever you can. I don’t necessarily mean container gardens/etc, but using veggies from the store to grow new ones in water trays left on the windowsill. There’s lots of guides online!

Keep in mind that this is in your house and can’t be affected by any right-to-garden laws, but I have heard of certain brand name veggie companies wanting to make it illegal. :) What they tend to do is trim off all that root fiber to make the veg “prettier” and thusly it can’t regrow. Or they deliberately make sterile crop, but that’s a whole other bucket of worms. Pick your veg wisely, especially from a farmer’s market if you can!

Hi! First off, I am not a medical doctor nor am I a licensed psychiatrist, so please supercede any of my information with what your personal doctor/care team says.

Second, when considering the therapeutic range of medication you cannot just look at increasing the mgs. The way you’ve calculated these trial dosages are following a raw formula (base starting dose multiplied by some number) and that isn’t taking in account the efficacy curve. That’s a really wordy way to put it, sorry. Consider that 100mg is around a 33% increase from the 50-200 range. You’d be looking for a similar 33% increase in the 20-40 range (27ish mg).

Basically, just because 100mg Zoloft was your starting dosage, you’d more realistically be looking at a dosage of 25-35mg Citalopram.

And depending on what the medication you’re looking at is made of, dosages can get wild and may not compare using the efficacy curve or my i-just-woke-up math. If you’re already looking at papers to determine personal dosages, try following along with the lowest dosage, see if it has effect, then take the next dosage up. Starting right at the 40mg may be too intense for your system overall, and could make your body intolerant of Citalopram if you go too hard. It’s much, much better to start lower than you think you need and work up. Best of luck!

Source: I have experience in drug research and development. Pictured below is my scratch math. +50 for each 33% increase on Zoloft, +7ish for each 33% increase on Citalopram. If anyone catches a mathematical error please lmk! :)