I tried a few, at one point a few weeks ago I thought I would stick with lemmy.world because (then) it wasn’t the most popular instance and seemed to have good resources… but then it became the most popular instance and got defederated by beehaw (and I was subscribed to a few beehaw communities). So I signed up to feddit.uk just because I’m from the UK and it seemed solid. I think if you have no strong niche interest then picking one made for your region/country is a pretty good bet.
I tried a few, at one point a few weeks ago I thought I would stick with lemmy.world because (then) it wasn’t the most popular instance and seemed to have good resources… but then it became the most popular instance and got defederated by beehaw (and I was subscribed to a few beehaw communities). So I signed up to feddit.uk just because I’m from the UK and it seemed solid. I think if you have no strong niche interest then picking one made for your region/country is a pretty good bet.