Think the original Lost but nearly all defensive items are removed from the item pool. On one hand that means no useless health ups clogging the item pools. On the other hand, that means no holy mantle or dead cat.

Overall I’d say that makes him a more consistent and more fun character, but I’m not sure if I’d call him easier. Losing the ability to find things like dead cat hurts.

IIRC (been almost a year since I’ve played Isaac), he has a higher damage stat as well, which is great.